The link is becoming clearer and clearer every day

Mitochondrial dysfunction caused by spike protein is the problem

Introduction

I have harped on about mitochondria for some time now. But the message doesn’t seem to be sinking in yet.
There are a number of syndromes identified which have very similar symptoms, and a large body of literature showing these syndromes have links or associations with mitochondrial dysfunction.

• Gulf war syndrome

• Chronic Lyme disease

• ME/CFS (Chronic fatigue syndrome)

• Floxed (Ciprofloxacin side effect)

• POTS

• Fibromyalgia

And now we also have…

Long Covid and Mitochondrial dysfunction

1. https://www.statnews.com/2023/08/09/long-covid-mitochondria-sars-cov-2/

   “What I think this paper does is cement the case for mitochondria as being one of the root causes of long Covid, Eric Topol, director of the Scripps Research Translational Institute, told STAT. He was not involved in the study. What we don’t know is whether or not this accounts for X percent, in which people who have mitochondrial dysfunction and key root cause. But I think this study really advances the notion that at least in some people, the mitochondrial effects of infection are playing a role”

2. https://www.healthrising.org/blog/2022/05/18/long-covid-exercise-cpet-mitochondria/

   “Then it got really interesting. As we’ve seen in ME/CFS, the long-COVID patients’ levels of lactate – a byproduct of anaerobic energy production – were increased. That suggested that the people with long COVID were rapidly blowing through their stores of clean energy produced by aerobic metabolism. We use aerobic metabolism in the mitochondria to produce most of our energy. It’s particularly needed when we do things like walk, run, or bike”

3. https://pubmed.ncbi.nlm.nih.gov/32510973/

   “Manipulations of host mitochondria by viral ORFs can release mitochondrial DNA (mtDNA) in the cytoplasm and activate mtDNA-induced inflammasome and suppress innate and adaptive immunity. We argue that a decline in ACE2 function in aged individuals, coupled with the age-associated decline in mitochondrial functions resulting in chronic metabolic disorders like diabetes or cancer, may make the host more vulnerable to infection and health complications to mortality.”

Similarities between Long Vax and Long Covid

Early after the roll out of the Safe and Effective vaccines. I heard of a number of cases of what reminded me of Chronic fatigue syndrome.

They came on quickly with fatigue and irritability. Post exertion malaise (PEM) and brain fog. Dizziness, pains, rashes and various other gastrointestinal disruptions.

1. https://www.drugdiscoverytrends.com/long-vax-phenomenon-gets-closer-look-in-recent-studies/

   “You see one or two patients and you wonder if it’s a coincidence,” says Anne Louise Oaklander, a neurologist and researcher at Harvard Medical School. “But by the time you’ve seen 10, 20,” she continues, trailing off. “Where there’s smoke, there’s fire.”

2. https://www.acsh.org/news/2023/07/12/and-now-long-vax-17190

   “Most reports of Long Vax involve 12 case reports or series involving very few patients. While both Long COVID and Long Vax have many symptoms, e.g., brain fog, fatigue and post-exertional malaise, the most extensive study zeroed in on one specific symptom, postural orthostatic tachycardia syndrome or POTS. We will return to POTS in a moment; let’s begin by looking at what the researchers found.”

3. https://www.forbes.com/sites/brucelee/2023/07/08/is-long-vax-syndrome-a-rare-covid-19-vaccine-side-effect-heres-whats-known/

   “It’s being called “Long Vax” not because they’ve gotten vaccinated with a particularly long needle but because the symptoms have resembled long Covid. This has included headaches, major fatigue, blood pressure issues and abnormal heart rates that have lasted days, weeks and potentially even longer.”

Spike protein damages mitochondria

Tiny little organelles that power your cells like engines. They take glucose (sugar) and combust it with air (oxygen) to produce the energy (ATP) to power you.

Mitochondria have their own DNA more similar to that of a bacteria, a circular bundle. And they float in the cellular cytoplasm where they act somewhat like middle management and help regulate the inner workings and daily operations of the cell. Sending signals, keeping vigil, communicating with the DNA found inside the nucleus.

But as they are not secure inside the nucleus of the cell they are much more prone to damage of intracellular invaders.

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046940/

   “Although S1 improved mitochondrial function in AC16 cells in the short term, prolonged S1 treatment led to mitochondrial dysfunction due to the disruption of Δψm, mitochondrial Ca²⁺ overload, accumulation of ROS, and alteration of mitochondrial dynamics. These effects of subunit S1 of the S protein translate into irreversible cardiac remodeling”

2. https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/covidwho-2138216

   “COVID-19 S1+S2 spike subunits promoted alterations in mitochondria metabolism suggesting a shift from aerobic towards anaerobic metabolism that was accompanied of high FXa production”

3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487226/

   “Thus, our data suggests that SARS-COV2 induces a significant inflammatory response, increased oxidative stress, inflammasome activation and mitochondrial dysfunction in microglial cells, all of which contribute to COVID associated neuropathology. This study provides important mechanistic insights into SARS-COV2 induced mitochondrial dysfunction which underlies COVID-19 associated neuropathology.”

Spike protein found in circulation after vaccination 

After the mRNA successfully enters the cell, our little pals go to work producing their special recipe. Alpha/Wuhan spike protein. Which is supposed to stimulate an immune response and allow our bodies to produce antibodies against this new invader.

But the spike protein is persistent and resistant and can escape from its tiny prison cell and run amuck in the plasma and fluids of our bodies.

1. https://pubmed.ncbi.nlm.nih.gov/36597886/#:~:text=A%20notable%20finding%20was%20that,test%3B%20P%3C0.0001).

   “A notable finding was that markedly elevated levels of full-length spike protein (33.9±22.4 pg/mL), unbound by antibodies, were detected in the plasma of individuals with postvaccine myocarditis, whereas no free spike was detected in asymptomatic vaccinated control subjects (unpaired t test; P<0.0001)”

2. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061025#

   “Immunoprofiling of vaccinated adolescents and young adults revealed that the mRNA vaccine–induced immune responses did not differ between individuals who developed myocarditis and individuals who did not. However, free spike antigen was detected in the blood of adolescents and young adults who developed post-mRNA vaccine myocarditis, advancing insight into its potential underlying cause.”

3. https://onlinelibrary.wiley.com/doi/10.1111/apm.13294

   “In 10 of 108 HCV patient samples, full-length or traces of SARS-CoV-2 spike mRNA vaccine sequences were found in blood up to 28 days after COVID-19 vaccination. Detection of mRNA vaccine sequences in blood after vaccination adds important knowledge regarding this technology and should lead to further research into the design of lipid-nanoparticles and the half-life of these and mRNA vaccines in humans.”

Mitochondria have more roles than energy production alone

1. https://www.medicalnewstoday.com/articles/320875

   “Because mitochondria perform so many different functions in different tissues, there are literally hundreds of different mitochondrial diseases. […] Because of the complex interplay between the hundreds of genes and cells that must cooperate to keep our metabolic machinery running smoothly, it is a hallmark of mitochondrial diseases that identical mtDNA mutations may not produce identical diseases.”

2. https://www.technologynetworks.com/cell-science/lists/5-roles-mitochondria-play-in-cells-289354

   “Traditionally referred to as the powerhouses of cells, mitochondria play a vital role in the conversion of energy from food into energy for biological processes. However, in recent years, a growing number of studies have demonstrated that mitochondria are also deeply involved in a range of other activities that enable cells to function efficiently and help to maintain a healthy body.”

3. https://portlandpress.com/biochemist/article/44/4/2/231672/Beyond-ATP-new-roles-of-mitochondria

   “Several mitochondrial metabolites can act as signalling molecules by regulating the activities of different cytosolic and nuclear enzymes. For instance, nucleic acid (i.e., DNA and RNA) methylation, and histone methylation and acetylation, which control gene expression, can be regulated by mitochondrial metabolites.”

Conclusions

Because mitochondria exist in almost every cell, of every body tissue, of every organ system in the body.
And because they have complex functions in each cell which can change the way the cell behaves, makes new proteins, lives, dies and gets energy.
The implication of free roaming spike protein produced after vaccination is concerning, as we can now see spike protein has been shown to permanently damage these little organelles.