Blood in, blood out

Blood disorder, business booms and the New World Order

Bitch, I got the blood gang at my disposal
We been iced out, whole crew stay frozen
Double cup, red codeine, blood potion

Bitch, I got the blood gang at my disposal
Ayy, ayy
Bitch, I got the blood gang at my disposal

- CXRPSE

Blood disorders are on the rise worldwide and it’s leading some investors to double down on emerging diagnostics and therapies. Markets are set to explode and steadily trend upwards, projecting billions in profits over the next decade.

Get rich or die trying - 50 cent

MARKET MAYHEM

Who reads market trends? I usually don’t. But when I went looking for trends in fairly rare blood conditions, I stumbled onto this peculiar line of enquiry.

The global non-cancerous blood disease market is anticipated to grow with a CAGR of 6.40% over the forecast period, 2022 - 2031:

Factors such as the growing need for the early diagnosis of different types of non-cancerous blood diseases, followed by the surge in the burden for hemoglobinopathies across the globe, are anticipated to drive the growth of the market in the coming years.

Growing Rare Hemoglobin Disorders and Rare Blood Cancers to Aid the Market Growth of Rare Hematology Disorders:

The market growth of rare hematology disorders is driven by the growing occurrence of rare hemoglobin disorders and rare blood cancers, which are predicted to contribute to the highest market share owing to the growing number of authorized products for these indications. Further, the rising demand for injectable dosage in the form segment is expected to propel the market growth as many of the new approvals are in injectable dosage forms.

Apheresis Market Regional Insights:

Due to the rising prevalence of various blood-related illnesses like kidney diseases, metabolic diseases, cancer, and neurological disorders, the region’s established healthcare infrastructure, and high patient awareness levels, it is anticipated that the North American market to grow rapidly throughout the forecast period. A new case of blood cancer is reported in the United States every three minutes, according to the Leukemia & Lymphoma Society (LLS).

Markets in medical testing and interventions are looking healthier than the majority of the population. The analysis of various different sectors all purport there is an expected increase in a host of medical conditions driving the market. None claim why this is happening in any detail. But the numbers and trends forecast are very optimistic and hint of a near certainty of healthy returns on money invested.

I’m living everyday like a hustle, another drug to juggle. Another day, another struggle. – Biggie Smalls

Aplastic Anaemia

Aplastic anemia is a condition that occurs when your body stops producing enough new blood cells. The condition leaves you fatigued and more prone to infections and uncontrolled bleeding.

1. A previously healthy 56-year-old male, who was not taking any medication, was referred to a clinic because of bleeding in the oral cavity after dental therapy. He had received a second dose of the Pfizer-BioNTech mRNA vaccine (three weeks after his first dose).

2. We reviewed the cases of all patients who presented to MD Anderson Cancer Center between January 2021 and December 2021 for pancytopenia. We identified patients who were diagnosed with aplastic anemia after receiving two doses of the SARS-CoV-2 vaccine.

3. A 60-year-old male patient presented to the emergency department with complaints of easy bruising and worsening epistaxis after receiving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Moderna mRNA vaccination.

Leukemia and blood cancers

“The increasing prevalence of leukemia across the globe represents one of the key factors driving the growth of the market."

The three main types of blood and bone marrow cancers are leukemia, lymphoma and myeloma: Leukemia is a blood cancer that originates in the blood and bone marrow. It occurs when the body creates too many abnormal white blood cells and interferes with the bone marrow's ability to make red blood cells and platelets.

1. Herein, we present a rare case of CMML after receiving the J&J COVID-19 vaccine with the rare association of limited scleroderma.

2. A 66-year-old man with no significant medical history except for hypertension, hypercholesterolemia and type 2 diabetes presented on September 1, 2021 with cervical lymphadenopathies that became recently apparent during a flu-like syndrome. The two doses of BNT162b2 mRNA vaccine had been administered, respectively, 5 and 6 months earlier in the left deltoid. Besides moderate asthenia, he did not report any constitutional symptom.

3. A 38-year-old man reporting vomiting and dizziness sought treatment at an emergency department. Smoldering multiple myeloma had been diagnosed 1.5 years before, but no laboratory abnormalities had been found in his most recent hospital visit 5 months earlier. He had received the Ad26.COV2.S vaccine (Johnson & Johnson vaccine) 2 days before the emergency department visit and experienced fever, chills, and myalgia 12–24 hours post vaccination, then nausea, recurrent vomiting, and general weakness 24–48 hours post vaccination.

Autoimmune Hemolytic Anemia (AIHA)

Autoimmune hemolytic anemia (AIHA) is a rare immune disorder. It happens when your body mistakes red blood cells as foreign substances and attacks them. Treatments include medication, surgery or, in rare cases, a blood transfusion.

1. The patient is a 66-year-old woman with long-term psoriatic arthritis. She received her second dose of the Moderna mRNA COVID vaccine three months prior to presenting with anemia.

2. A 33-year-old female was admitted because of symptoms of severe anemia. She was apparently well until 1 day after the covid-19 booster vaccination, when she developed flu-like illness and pain at the injection site, for which she took paracetamol.

3. The case was a 42-year-old female with a past medical history of hypertension, congenitally deaf and mute (uses sign language for communication). The patient reported the onset of these symptoms was a week after getting her first dose of the COVID-19 mRNA-1273 vaccine on April 7, 2021. Since then, her symptoms had been progressive and got severe enough to limit her physical activity in the last few days.

4. A 67-year-old man was admitted to the emergency department 22 days after receiving his third dose of the Pfizer-BioNTech mRNA COVID-19 vaccine. The patient reported a five-day history of fever, fatigue and general weakness, with jaundice and dark urine. Moreover, he suffered from diarrhea and clinically significant anorexia.

Evans syndrome (ES)

Evans syndrome is a rare disorder in which the body’s immune system produces antibodies that mistakenly destroy red blood cells, platelets and sometimes certain white blood cell known as neutrophils. This leads to abnormally low levels of these blood cells in the body (cytopenia).

1. An 85-year-old male presented to the emergency department (ED) of Sant'Anna and San Sebastiano Hospital in Caserta, Italy, in March 2021, due to the appearance of a large hematoma that extended from the left deltoid to the forearm, with the evidence of widespread ecchymosis on the right arm and legs. The patient had received the Comirnaty SARS-CoV-2 vaccine at the beginning of March on his left arm, detecting first local ecchymosis 48 hours later.

2. Evans syndrome associated with SLE after BNT162b2 mRNA coronavirus disease 2019 (COVID-19) vaccination in a 53-year-old woman.

THE DUCK TEST

"If it looks like a duck, swims like a duck, and quacks like a duck, then it probably is a duck."

The test implies that a person can identify an unknown subject by observing that subject's habitual characteristics.

It is sometimes used to counter abstruse arguments that something is not what it appears to be.

The simplest explanation sometimes is the explanation.